Search

Publications

2016

Heart rate – a novel target for treatment of Peripartum Cardiomyopathy?

downloadDownload

Imamdin A, Lecour S, Sliwa K, Azibani F. Heart rate – a novel target for treatment of Peripartum Cardiomyopathy? SA Heart Journal, 13(4): 304-307

2016, Peer Reviewed articles

Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

downloadDownload

GBD 2015 Maternal Mortality Collaborators.  Lancet. 2016 Oct 8;388(10053):1775-1812.

2016, Peer Reviewed articles

Cardiology-cardiothoracic subspeciality training in South Africa: a position paper of the South Africa Heart Association.

downloadDownload

Sliwa K, Zühlke L, Kleinloog R, Doubell A, Ebrahim I, Essop M, Kettles D, Jankelow D, Khan S, Klug E, Lecour S, Marais D, Mpe M, Ntsekhe M, Osrin L, Smit F, Snyders A, Theron JP, Thornton A, Chin A, van der Merwe N, Dau E, Sarkin A.  Cardiology-cardiothoracic subspeciality training in South Africa: a position paper of the South Africa Heart Association.  Cardiovasc J Afr. 2016 May/Jun;27(3):188-193. doi: 10.5830/CVJA-2016-063.

2016, Peer Reviewed articles

Ischaemic conditioning and targeting reperfusion: a 30 year voyage of discovery.

downloadDownload

Hausenloy DJ, Barrabes J, Bøtker HE, Davidson SM, Di Lisa F, Downey J, Engstrom T, Ferdinandy P, Carbrera-Fuentes H, Heusch G, Ibanez B, Iliodromitis E, Inserte J, Jennings R, Kalia N, Kharbanda R, Lecour S, Marber M, Miura T, Ovize M, Perez-Pinzon M, Piper M, Przyklenk K, Schmidt M, Redington A, Ruiz-Meana M, Vilahur G, Vinten-Johansen J, Yellon DM, Garcia-Dorado D.  Ischaemic conditioning and targeting reperfusion: a 30 year voyage of discovery.   Basic Res Cardiol, 2016, 111(6):70.

2016, Peer Reviewed articles

Protection from Cardiovascular Disease Due to Increased High-Density Lipoprotein Cholesterol in African Black Populations: Myth or Reality?

downloadDownload

Nicholas J. Woudberg, Julia H. Goedecke, Sandrine Lecour.  Protection from Cardiovascular Disease Due to Increased High-Density Lipoprotein Cholesterol in African Black Populations: Myth or Reality?  Ethnicity & Disease, Volume 26, Number 4, Autumn 2016

2016, Peer Reviewed articles

Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution.

downloadDownload

Woudberg NJ, Goedecke JH, Blackhurst D, Frias M, James R, Opie LH, Lecour S.  Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution.  Lipids Health Dis. 2016 May 11;15:92. doi: 10.1186/s12944-016-0257-9.

2016, Peer Reviewed articles

Assessing perinatal depression as an indicator of risk for pregnancy-associated cardiovascular disease.

downloadDownload

Nicholson L, Lecour S, Wedegärtner S, Kindermann I, Böhm M, Sliwa K.  Assessing perinatal depression as an indicator of risk for pregnancy-associated cardiovascular disease.  Cardiovasc J Afr. 2016 Mar-Apr;27(2):119-22.

2016, Peer Reviewed articles

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".

downloadDownload

Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT.  From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".  Basic Res Cardiol. 2016 Nov;111(6):69. Review.

2016, Peer Reviewed articles

Melatonin has multiorgan effects 

downloadDownload

Lionel H. Opie, Sandrine Lecour.  Melatonin has multiorgan effects.Eur Heart J Cardiovasc Pharmacother. 2016 Aug 8. pii: pvv037

2016, Peer Reviewed articles 

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.

downloadDownload

Cabrera-Fuentes HA, Alba-Alba C, Aragones J, Bernhagen J, Boisvert WA, Bøtker HE, Cesarman-Maus G, Fleming I, Garcia-Dorado D, Lecour S, Liehn E, Marber MS, Marina N, Mayr M, Perez-Mendez O, Miura T, Ruiz-Meana M, Salinas-Estefanon EM, Ong SB, Schnittler HJ, Sanchez-Vega JT, Sumoza-Toledo A, Vogel CW, Yarullina D, Yellon DM, Preissner KT, Hausenloy DJ.  Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.  Basic Res Cardiol. 2016 Jan;111(1):7. doi: 10.1007/s00395-015-0527-0.

20016, Peer Reviewed articles

Cardioprotective strategies are not "one size fits all".  Is it time to consider personalised medicine?

downloadDownload

Sandrine Lecour, Nkanyiso Hadebe, Lionel Opie.  Cardioprotective strategies are not "one size fits all".  Is it time to consider personalised medicine?  SA Heart 13: 2

2016, Peer Reviewed articles

Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy.

downloadDownload

Johann Bauersachs, Mattia Arrigo, Denise Hilfiker‐Kleiner, Christian Veltmann, Andrew JS Coats, Maria G Crespo‐Leiro, Rudolf A De Boer, Peter van der Meer, Christoph Maack, Frederic Mouquet, Mark C Petrie, Massimo F Piepoli, Vera Regitz‐Zagrosek, Maria Schaufelberger, Petar Seferovic, Luigi Tavazzi, Frank Ruschitzka, Alexandre Mebazaa, Karen Sliwa.  Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy.  European Journal of Heart Failure DOI: 10.1002/ejhf.586

2016, Peer Reviewed articles 

Pulmonary hypertension and pregnancy outcomes: data from the Registry Of Pregnancy and Cardiac Disease (ROPAC) of the European Society of Cardiology

downloadDownload

Karen Sliwa, Iris M van Hagen, Werner Budts, Lorna Swan, Gianfranco Sinagra, Maryanne Caruana, Manuel Vazquez Blanco, Lodewijk J Wagenaar, Mark R Johnson, Gary Webb, Roger Hall, Jolien W Roos‐Hesselink.  Pulmonary hypertension and pregnancy outcomes: data from the Registry Of Pregnancy and Cardiac Disease (ROPAC) of the European Society of Cardiology. European Journal of Heart Failure  DOI: 10.1002/ejhf.594

2016, Peer Reviewed articles

The causes, treatment, and outcome of pulmonary hypertension in Africa: Insights from the Pan African Pulmonary Hypertension Cohort (PAPUCO) Registry

downloadDownload

Friedrich Thienemann, Anastase Dzudie, Ana O Mocumbi, Lori Blauwet, Mahmoud U Sani, Kamilu M Karaye, Okechukwu S Ogah, Irina Mbanze, Amam Mbakwem, Patience Udo, Kemi Tibazarwa, Albertino Damasceno, Ashley K Keates, Simon Stewart, Karen Sliwa.  The causes, treatment, and outcome of pulmonary hypertension in Africa: Insights from the Pan African Pulmonary Hypertension Cohort (PAPUCO) Registry.  International Journal of Cardiology 221 (2016) 205–211

2016, Peer Reviewed articles

Cardiovascular disease in pregnancy: the South African perspective.

downloadDownload

J Anthony, A Sarkin, K Sliwa.  Cardiovascular disease in pregnancy: the South African perspective. Cardiovascular journal of Africa.  2016 Mar-Apr;27(2):59.

2016, Peer Reviewed articles

Risk assessment for pregnancy with cardiac disease—a global perspective

downloadDownload

K Sliwa, J Anthony.  Risk assessment for pregnancy with cardiac disease—a global perspective.  European Journal of Heart Failure (2016) 18, 534–536.

2016, Peer Reviewed artciles

Bi treatment with hydralazine/nitrates vs. placebo in Africans admitted with acute HEart Failure (BA‐HEF)

downloadDownload

Karen Sliwa, Albertino Damasceno, Beth A Davison, Bongani M Mayosi, Mahmoud U Sani, Okekuchwu Ogah, Charles Mondo, Dike Ojji, Anastase Dzudie, Charles Kouam Kouam, Gerald Yonga, Serigne Abdou Ba, Elijah Ogola, Christopher Edwards, Gad Cotter.  Bi treatment with hydralazine/nitrates vs. placebo in Africans admitted with acute HEart Failure (BA‐HEF).  European journal of heart failure. DOI: 10.1002/ejhf.581

2016, Peer Reviewed articles

Maternal heart health

downloadDownload

K Sliwa, J Anthony, D Hilfiker-Kleiner.  Maternal heart health.  The Heart of Africa: Clinical profile of an evolving burden of heart disease 

2016, Peer Reviewed articles

The spectrum of heart disease in urban Africans: The Heart of Soweto Study

downloadDownload

MJ Carrington, K Sliwa, S Stewart.  The spectrum of heart disease in urban Africans: The Heart of Soweto Study.  The Heart of Africa: Clinical profile of an evolving burden of heart disease in Africa

2016, Peer Reviewed articles

Human immunodeficiency virus–related heart disease

downloadDownload

F Thienemann, MJ Carrington, K Sliwa, M Ntsekhe, S Stewart.  Human immunodeficiency virus–related heart disease.  The Heart of Africa: Clinical profile of an evolving burden of heart disease in Africa

2016, Peer Reviewed articles

Late maternal deaths: a neglected responsibility

downloadDownload

K Sliwa, J Anthony.  Late maternal deaths: a neglected responsibility.  The Lancet.  387 (10033), 2072-2073    

2016, Peer Reviewed articles

Hearts in sight

downloadDownload

K Sliwa.  Hearts in sight.  European Heart J.  37 (3), 212-214

2016, Peer Reviewd articles

Cardiovascular Topics

downloadDownload

P Soma-Pillay, J Seabe, K Sliwa.  Cardiovascular Topics.  Cardiovascular journal of Africa 2

2016, Peer Reviewed articles

A global view of Pulmonary hypertension

downloadDownload

Marius M Hoeper, Marc Humbert, Rogerio Souza, Majdy Idrees, Steven M Kawut, Karen Sliwa-Hahnle, Zhi-Cheng Jing, J Simon R Gibbs.  A global view of Pulmonary hypertension.  The Lancet Respir Med.  doi:10.1016/S2213-2600(15)00543-3

2016, Peer Reviewed articles

Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.

downloadDownload

Maryam Fish, Gasnat Shaboodien, Sarah Kraus, Karen Sliwa, Christine E Seidman, Michael A Burke, Lia Crotti, Peter J Schwartz, Bongani M Mayos.  Scientific Reports.  6:22235. doi: 10.1038/srep22235.

2016, Peer Reviewed articles

Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance.

downloadDownload

Mebazaa A, Tolppanen H, Mueller C, Lassus J, DiSomma S, Baksyte G, Cecconi M, Choi DJ, Cohen Solal A, Christ M, Masip J, Arrigo M, Nouira S, Ojji D, Peacock F, Richards M, Sato N, Sliwa K, Spinar J, Thiele H, Yilmaz MB, Januzzi J. Acute heart failure and cardiogenic shock: a multidisciplinary practical guidance.  Intensive Care Med. 2016 Feb;42(2):147-63

2016, Peer Reviewed articles

Heart failure in low- and middle-income countries: Background, rationale, and design of the INTERnational Congestive Heart Failure Study (INTER-CHF).

downloadDownload

Dokainish H, Teo K, Zhu J, Roy A, Al-Habib K, ElSayed A, Palileo L, Jaramillo PL, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Dorairaj P, Huffman M, Badr A, Elmaghawry M, Damasceno A, Belley-Cote E, Harkness K, Grinvalds A, McKelvie R, Yusuf S. Heart failure in low- and middle-income countries: Background, rationale, and design of the INTERnational Congestive Heart Failure Study (INTER-CHF). Am Heart J. 2015 Oct;170(4):627-634

2016, Peer Reviewd articles

Comparison of the American PPCM Registry Data With International Registries

downloadDownload

Denise Hilfiker-Kleiner, PhD; Karen Sliwa, MD, PhD; Johann Bauersachs, MD.  Comparison of the American PPCM Registry Data With International Registries.  J Am Coll Cardiol. 2016;67(6):733-734

2016, Peer Reviewed articles

Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013:  Findings From the Global Burden of Disease 2013 Study.

downloadDownload

Global Burden of Disease Pediatrics Collaboration.  Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013:  Findings From the Global Burden of Disease 2013 Study.

2016, Peer Reviwed articles 

Impact of Socioeconomic Status, Ethnicity, and Urbanization on Risk Factor Profiles of Cardiovascular Disease in Africa.

downloadDownload

Karen Sliwa, Letitia Acquah, Bernard J. Gersh, Ana Olga Mocumbi.  Impact of Socioeconomic Status, Ethnicity, and Urbanization on Risk Factor Profiles of Cardiovascular Disease in Africa. Circulation. 2016;133:1199-1208

2016, Peer Reviewed articles

Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.

downloadDownload

Eva M. Lonn, M.D., Jackie Bosch, Ph.D., Patricio López‑Jaramillo, M.D., Ph.D., Jun Zhu, M.D., Lisheng Liu, M.D., Prem Pais, M.D., Rafael Diaz, M.D., Denis Xavier, M.D., Karen Sliwa, M.D., Ph.D., Antonio Dans, M.D., Alvaro Avezum, M.D., Ph.D., Leopoldo S. Piegas, M.D., Ph.D., Katalin Keltai, M.D., Ph.D., Matyas Keltai, M.D., Ph.D., Irina Chazova, M.D., Ph.D., Ron J.G. Peters, M.D., Ph.D., Claes Held, M.D., Ph.D., Khalid Yusoff, M.D., Basil S. Lewis, M.D., Petr Jansky, M.D., Alexander Parkhomenko, M.D., Ph.D., Kamlesh Khunti, M.D., Ph.D., William D. Toff, M.D., Christopher M. Reid, Ph.D., John Varigos, B.Sc., Lawrence A. Leiter, M.D., Dora I. Molina, M.D., Robert McKelvie, M.D., Ph.D., Janice Pogue, Ph.D.,* Joanne Wilkinson, B.A., Hyejung Jung, M.Sc., Gilles Dagenais, M.D., and Salim Yusuf, M.B., B.S., D.Phil., for the HOPE-3 Investigators.  Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.  N Engl J Med. 2016 Apr 2

2016, Peer Reviwed articles

Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease.

downloadDownload

S. Yusuf, J. Bosch, G. Dagenais, J. Zhu, D. Xavier, L. Liu, P. Pais, P. López‑Jaramillo, L.A. Leiter, A. Dans, A. Avezum, L.S. Piegas, A. Parkhomenko, K. Keltai, M. Keltai, K. Sliwa, R.J.G. Peters, C. Held, I. Chazova, K. Yusoff, B.S. Lewis, P. Jansky, K. Khunti, W.D. Toff, C.M. Reid, J. Varigos, G. Sanchez‑Vallejo, R. McKelvie, J. Pogue,* H. Jung, P. Gao, R. Diaz, and E. Lonn, for the HOPE-3 Investigators.  Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease. N Engl J Med. 2016

2016, Peer Reviewed articles

Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease.

downloadDownload

Yusuf S, Lonn E, Pais P, Bosch J, López-Jaramillo P, Zhu J, Xavier D, Avezum A, Leiter LA, Piegas LS, Parkhomenko A, Keltai M, Keltai K, Sliwa K, Chazova I, Peters RJ, Held C, Yusoff K, Lewis BS, Jansky P, Khunti K, Toff WD, Reid CM, Varigos J, Accini JL, McKelvie R, Pogue J, Jung H, Liu L, Diaz R, Dans A, Dagenais G; HOPE-3 Investigators.  Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease.  N Engl J Med. 2016 Apr 2.

2016, Peer Reviwed articles

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

downloadDownload

Madonna R, Van Laake LW, Davidson SM, Engel FB, Hausenloy DJ, Lecour S, Leor J, Perrino C, Schulz R, Ytrehus K, Landmesser U, Mummery CL, Janssens S, Willerson J, Eschenhagen T, Ferdinandy P, Sluijter JP.  Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.  Eur Heart J. 2016 Apr 7. pii: ehw113

2016, Peer Reviewed articles

Right Ventricular Systolic Dysfunction Is Common in Hypertensive Heart Failure: A Prospective Study in Sub-Saharan Africa

downloadDownload 

Ojji DB, Lecour S, Atherton JJ, Blauwet LA, Alfa J, Sliwa K. Right Ventricular Systolic Dysfunction Is Common in Hypertensive Heart Failure: A Prospective Study in Sub-Saharan Africa.  PLoS One. 2016 Apr 13;11(4):e0153479

2016, Peer Reviewed articles

Role of toll-like receptor 4 in melatonin-induced cardioprotection

downloadDownload

Nduhirabandi F, Lamont K, Albertyn Z, Opie LH, Lecour S. Role of toll-like receptor 4 in melatonin-induced cardioprotection.  J Pineal Res. 2016 Jan;60(1):39-47

2016, Peer Reviwed articles

The importance of cardiovascular pathology contributing to maternal death:  Confidential Enquiry into Maternal Deaths in South Africa, 2011-2013

downloadDownload

Priya Soma-Pillay, J Seabe, Karen Sliwa.  The importance of cardiovascular pathology contributing to maternal death:  Confidential Enquiry into Maternal Deaths in South Africa, 2011-2013. Cardiovasc J Africa 2016; 27

2016, Peer Reviewed articles

Heart Failure in Africa, Asia, the Middle East and South America.  The INTER_CHF study.

downloadDownload

Dokainish H, Teo K, Zhu J,  Sliwa K, Yusuf S; INTER-CHF Investigators (Appendix 1).  Heart Failure in Africa, Asia, the Middle East and South America.  The INTER_CHF study. Int J Cardiol. 2016 Feb 1;204:133-41

2016, Peer Reviewed articles

Heart failure in sub-Saharan Africa: A clinical approach

downloadDownload

S Kraus,  G Ogunbanjo,  K Sliwa, NAB Ntusi. Heart failure in sub-Saharan Africa: A clinical approach.

2016, Peer Reviewed articles