Publications

2020

N‐terminal pro BNP and galectin‐3 are prognostic biomarkers of acute heart failure in sub‐Saharan Africa: lessons from the BAHEF trial.

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Mahmoud U. Sani, Albertino Damasceno, Beth A. Davison, Gad Cotter, Bongani M. Mayosi,  Christopher Edwards, Feriel Azibani, Tasneem Adam, Gulnaze Arif, Neusa Jessen, Karen Sliwa.  N‐terminal pro BNP and galectin‐3 are prognostic biomarkers of acute heart failure in sub‐Saharan Africa: lessons from the BAHEF trial.  ESC HEART FAILURE doi.org/10.1002/ehf2.13032

2020, Peer Reviewed Articles

Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial

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Blom DJ, Harada-Shiba M, Rubba P, Gaudet D, Kastelein JJP, Charng MJ, Pordy R, Donahue S, Ali S, Dong Y, Khilla N, Banerjee P, Baccara-Dinet M, Rosenson RS.  Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial.  J Am Coll Cardiol. 2020 Jul 14;76(2):131-142. doi: 10.1016/j.jacc.2020.05.027

2020, Peer Reviewed Articles

The challenge of multiple cardiovascular risk factor control outside Western Europe: Findings from the International ChoLesterol management Practice Study

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Blom DJ, Santos RD, Daclin V, Mercier F, Ruiz AJ, Danchin N; ICLPS study group. The challenge of multiple cardiovascular risk factor control outside Western Europe: Findings from the International ChoLesterol management Practice Study.  Eur J Prev Cardiol. 2020 Sep;27(13):1403-1411. doi: 10.1177/2047487319871735

2020, Peer Reviewed Articles

Risk Factors of In-Hospital Mortality in Patients Treated for Pneumonia at a Tertiary Care Centre in Switzerland.

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Christian Elsenera, Patrick E. Beelera, Edouard Battegaya, Braimoh Bellod, Friedrich Thienemanna.  Risk Factors of In-Hospital Mortality in Patients Treated for Pneumonia at a Tertiary Care Centre in Switzerland.   Respiration 2020;99:637–645doi.org/10.1159/000508666

2020, Peer Reviwed Articles

Multimorbidity and cardiovascular disease: a perspective on low- and middle-income countries

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Thienemann F, Ntusi NAB, Battegay E, Mueller BU, Cheetham MMultimorbidity and cardiovascular disease: a perspective on low- and middle-income countries.  Cardiovasc Diagn Ther. 2020 Apr;10(2):376-385. doi: 10.21037/cdt.2019.09.09

2020, Peer Reviewed Articles

Elevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township.

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Peterson TE, Baker JV, Wong LY, Rupert A, Ntusi NAB, Esmail H, Wilkinson R, Sereti I, Meintjes G, Ntsekhe M, Thienemann FElevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township.  ESC Heart Fail. 2020 Oct;7(5):3246-3251. doi: 10.1002/ehf2.12849

2020, Peer Reviwed Articles

The Fourth European-South African Cardiovascular Research Workshop: Strengthening cardiovascular research networking between the southern and northern hemispheres

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Sandrine Lecour, Derek J Hausenloy, Rosalinda Madonna.  The Fourth European-South African Cardiovascular Research Workshop: Strengthening cardiovascular research networking between the southern and northern hemispheres.  European Heart Journal, Volume 41, Issue 2, 7 January 2020, Pages 203–204, doi.org/10.1093/eurheartj/ehz934

2020, Peer Reviewed Articles

Linking LOXL2 to Cardiac Interstitial Fibrosis

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Melisse Erasmus, Ebrahim Samodien, Sandrine Lecour, Martin Cour, Oscar Lorenzo, Phiwayinkosi Dludla, Carmen Pheiffer and Rabia Johnson.  Linking LOXL2 to Cardiac Interstitial Fibrosis. Int J Mol Sci. 2020 Aug; 21(16): 5913.  doi: 10.3390/ijms21165913

2020, Peer Reviewed Articles

Memories of a Mentee: Professor Sandrine Lecour Pharm D. PhD remembers her mentor Lionel Opie who was an inspiration to many

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Sandrine Lecour.  Memories of a Mentee: Professor Sandrine Lecour Pharm D. PhD remembers her mentor Lionel Opie who was an inspiration to many.  European Heart Journal, Volume 41, Issue 17, 1 May 2020, Pages 1621–1622, https://doi.org/10.1093/eurheartj/ehaa199

2020, Peer Reviwed Articles

Hyperlipidaemia and cardioprotection: Animal models for translational studies

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Ioanna Andreadou , Rainer Schulz , Lina Badimon , Adriana Adameová , Petra Kleinbongard, Sandrine Lecour, Panagiota-Efstathia Nikolaou, Ines Falcão-Pires, Gemma Vilahur, Nicholas Woudberg, Gerd Heusch, Péter Ferdinandy.  Hyperlipidaemia and cardioprotection: Animal models for translational studies.  Br J Pharmacol  . 2020 Dec;177(23):5287-5311. doi: 10.1111/bph.14931

2020, Peer Reviewed Articles

Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection.

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Huige Li , Aoife B Kilgallen , Thomas Münzel, Eva Wolf, Sandrine Lecour, Rainer Schulz, Andreas Daiber , Linda W Van Laake.  Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection.  Br J Pharmacol . 2020 Dec;177(23):5393-5412. doi: 10.1111/bph.14949

2020, Peer Reviewed Articles

Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

J.R. Teerlink, R. Diaz, G.M. Felker, J.J.V. McMurray, M. Metra, S.D. Solomon, K.F. Adams, I. Anand, A. Arias‑Mendoza, T. Biering‑Sørensen, M. Böhm, D. Bonderman, J.G.F. Cleland, R. Corbalan, M.G. Crespo‑Leiro, U. Dahlström, L.E. Echeverria, J.C. Fang, G. Filippatos, C. Fonseca, E. Goncalvesova, A.R. Goudev, J.G. Howlett, D.E. Lanfear, J. Li, M. Lund, P. Macdonald, V. Mareev, S. Momomura, E. O’Meara, A. Parkhomenko, P. Ponikowski, F.J.A. Ramires, P. Serpytis, K. Sliwa, J. Spinar, T.M. Suter, J. Tomcsanyi, H. Vandekerckhove, D. Vinereanu, A.A. Voors, M.B. Yilmaz, F. Zannad, L. Sharpsten, J.C. Legg, C. Varin, N. Honarpour, S.A. Abbasi, F.I. Malik, and C.E. Kurtz, for the GALACTIC-HF Investigators*.  Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.  N Engl J Med DOI: 10.1056/NEJMoa2025797   

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2020, Peer Reviewed Articles

COVID-19 and the cardiovascular system in pregnancy

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AS Herrey, A Osman, P Soma-Pillay, K Sliwa, NAB Ntusi.  COVID-19 and the cardiovascular system in pregnancy.  DOI: https://doi.org/10.24170/17-3-4375

2020, Peer Reviewed articles

Racism in medicine, science and in medical publishing

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Ntobeko Ntusi.  Racism in medicine, science and in medical publishing.  SA Heart Journal, Vol 17, No 3 (2020)

2020, Peer Reviewed articles

Molecular Epidemiology of non-Invasive and Invasive Group A Streptococcal Infections in Cape Town.

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Barth DD, Naicker P, Engel K, Muhamed B, Basera W, Mayosi BM, Dale JB, Engel ME.  Molecular Epidemiology of non-Invasive and Invasive Group A Streptococcal Infections in Cape Town. mSphere 4:e00421-19.

2020,Peer Reviewed Articles

Genetic variants in rheumatic fever and rheumatic heart disease.

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Muhamed B, Shaboodien G, Engel ME.  Genetic variants in rheumatic fever and rheumatic heart disease.  Am J Med Genet C Semin Med Genet. 2020 Mar;184(1):159-177. 

2020, Peer Reviewed articles

Subclinical anthracycline therapy-related cardiac Dysfunction: an ignored stage B heart failure in an African population.

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Zhang WZ, Azibani F, Sliwa K.  Subclinical anthracycline therapy-related cardiac Dysfunction: an ignored stage B heart failure in an African population.  Cardiovasc J Afr. 2020 Jun 24;31:1-5. doi: 10.5830/CVJA-2020-013.

2020, Peer Reviewed Articles

Management of Cardiovascular Disease Patients With Confirmed or Suspected COVID-19 in Limited Resource Settings.

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Prabhakaran D, Perel P, Roy A, Singh K, Raspail L, Faria-Neto JR, Gidding SS, Ojji D, Hakim F, Newby LK, Stępińska J, Lam CSP, Jobe M, Kraus S, Chuquiure-Valenzuela E, Piñeiro D, Khaw KT, Bahiru E, Banerjee A, Narula J, Pinto FJ, Wood DA, Sliwa K.  Management of Cardiovascular Disease Patients With Confirmed or Suspected COVID-19 in Limited Resource Settings.  Glob Heart. 2020 Jul 1;15(1):44. doi: 10.5334/gh.823.

2020, Peer Reviewed Articles

Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry.

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Sliwa K, Petrie MC, van der Meer P, Mebazaa A, Hilfiker-Kleiner D, Jackson AM, Maggioni AP, Laroche C, Regitz-Zagrosek V, Schaufelberger M, Tavazzi L, Roos-Hesselink JW, Seferovic P, van Spaendonck-Zwarts K, Mbakwem A, Böhm M, Mouquet F, Pieske B, Johnson MR, Hamdan R, Ponikowski P, Van Veldhuisen DJ, McMurray JJV, Bauersachs J.  Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry.  Eur Heart J. 2020 Aug 25:ehaa455. doi: 10.1093/eurheartj/ehaa455

2020, Peer Reviewed Articles

A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry.

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Joseph P, Dokainish H, McCready T, Budaj A, Roy A, Ertl G, Gomez-Mesa JE, Leong D, Ezekowitz J, Hage C, Lanas F, Maggioni AP, Sliwa K, Zhu J, Rouleau J, Balasubramanian K, Yusuf S; G-CHF Investigators.  A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry.  Am Heart J. 2020 Sep;227:56-63. doi: 10.1016/j.ahj.2020.06.002.

2020, Peer Reviewed Articles

Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases.

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Sabeel S, Motaung B, Ozturk M, Mukasa S, Kengne AP, Blom D, Sliwa K, Nepolo E, Günther G, Wilkinson RJ, Schacht C, Thienemann F, Guler R.  Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases.  BMJ Open. 2020 Aug 13;10(8):e039034. doi: 10.1136/bmjopen-2020-039034.

2020, Peer Reviewed Articles

Correction: Management of Cardiovascular Disease Patients With Confirmed or Suspected COVID-19 in Limited Resource Settings.

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Prabhakaran D, Perel P, Roy A, Singh K, Raspail L, Faria-Neto JR, Gidding SS, Ojji D, Hakim F, Newby LK, Stępińska J, Lam CSP, Jobe M, Kraus S, Chuquiure-Valenzuela E, Piñeiro D, Khaw KT, Bahiru E, Banerjee A, Narula J, Pinto FJ, Wood DA, Sliwa K.  Correction: Management of Cardiovascular Disease Patients With Confirmed or Suspected COVID-19 in Limited Resource Settings.  Glob Heart. 2020 Aug 7;15(1):54. doi: 10.5334/gh.885

2020, Peer Reviewed Articles

Improving Translational Research in Sex-specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart.

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Perrino C, Ferdinandy P, Bøtker HE, Brundel BJJM, Collins P, Davidson SM, den Ruijter HM, Engel FB, Gerdts E, Girao H, Gyöngyösi M, Hausenloy DJ, Lecour S, Madonna R, Marber M, Murphy E, Pesce M, Regitz-Zagrosek V, Sluijter JPG, Steffens S, Gollmann-Tepeköylü C, Van Laake LW, Van Linthout S, Schulz R, Ytrehus K.  Improving Translational Research in Sex-specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart.  Cardiovasc Res. 2020 Jun 2:cvaa155. doi: 10.1093/cvr/cvaa155.

2020, Peer Reviewed Articles

Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model.

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Johnson R, Nxele X, Cour M, Sangweni N, Jooste T, Hadebe N, Samodien E, Benjeddou M, Mazino M, Louw J, Lecour S.  Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model.  Sci Rep. 2020 Jul 23;10(1):12352. doi: 10.1038/s41598-020-69254-x

2020, Peer Reviewed Articles

HIV-related Cardiovascular Disease: Any role for High-density Lipoproteins?

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Hudson PAJ, Woudberg NJ, Kamau FM, Strijdom H, Frias MA, Lecour S.  HIV-related Cardiovascular Disease: Any role for High-density Lipoproteins?  Am J Physiol Heart Circ Physiol. 2020 Oct 2. doi: 10.1152/ajpheart.00445.2020

2020, Peer Reviewed Articles

Linking LOXL2 to Cardiac Interstitial Fibrosis.

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Erasmus M, Samodien E, Lecour S, Cour M, Lorenzo O, Dludla P, Pheiffer C, Johnson R.  Linking LOXL2 to Cardiac Interstitial Fibrosis.  Int J Mol Sci. 2020 Aug 18;21(16):5913. doi: 10.3390/ijms21165913

2020, Peer Reviewed Articles

SAFE pathway and conditioning: from discovery to its effectiveness in the presence of cardiovascular risk factors

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Aqeela Imamdin, Nkanyiso Hadebe, Sandrine Lecour.  SAFE pathway and conditioning: from discovery to its effectiveness in the presence of cardiovascular risk factors.  Conditioning Medicine 2020, 3(2):98-103.

2020, Peer Reviewed Articles

Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials

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Michael Böhm, Helmut Schumacher, Koon K Teo, Eva M Lonn, Felix Mahfoud, Christian Ukena, Johannes FE Mann, Giuseppe Mancia, Josep Redon, Roland E Schmieder, Karen Sliwa, Nikolaus Marx, Michael A Weber, Bryan Williams, Salim Yusuf.  Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials.  European Heart Journal (2020) 41, 231–238

2020, Peer Reviewed Articles

Pregnant Women With Uncorrected Congenital Heart Disease: Heart Failure and Mortality

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Karen Sliwa, Lucia Baris, Christoph Sinning, Elvin Zengin-Sahm, Lina Gumbiene, Israa F Yaseen, Ghada Youssef, Mark Johnson, Hasan Al-Farhan, Malgorzata Lelonek, Roger Hall, Jolien Roos-Hesselink.  Pregnant Women With Uncorrected Congenital Heart Disease: Heart Failure and Mortality.  JACC: Heart Failure Volume 8, Issue 2.  DOI: 10.1016/j.jchf.2019.09.001

2020, Peer Reviewed Articles

Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective

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Matthew Fomonyuy Yuyun, Karen Sliwa, Andre Pascal Kengne, Anna Olga Mocumbi, Gene Bukhman.  Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective.  Global Heart. 2020;15(1):15.

2020, Peer Reviewed Articles

World Heart Federation Briefing on Prevention: Coronavirus Disease 2019 (COVID-19) in low-income countries

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Friedrich Thienemann, Fausto Pinto, Diederick E Grobbee, Michael Boehm, Nooshin Bazargani, Junbo Ge, Karen Sliwa.  World Heart Federation Briefing on Prevention: Coronavirus Disease 2019 (COVID-19) in low-income countries.  World Heart Journal, 15(1):23.

2020, Peer Reviewed Articles

Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers.

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Azibani F, Pfeffer TJ, Ricke-Hoch M, Dowling W, Pietzsch S, Briton O, Baard J, Abou Moulig V, König T, Berliner D, Libhaber E, Schlothauer S, Anthony J, Lichtinghagen R, Bauersachs J, Sliwa K, Hilfiker-Kleiner D.  Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers.  ESC Heart Fail. 2020 Feb 17. doi: 10.1002/ehf2.12553

2020, Peer Reviewed Articles

Effectiveness of Implanted Cardiac Rhythm Recorders With Electrocardiographic Monitoring for Detecting Arrhythmias in Pregnant Women With Symptomatic Arrhythmia and/or Structural Heart Disease: A Randomized Clinical Trial.

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Karen Sliwa, Feriel Azibani, Mark R Johnson, Charle Viljoen, Johann Baard, Ayesha Osman, Olivia Briton, Mpiko Ntsekhe, Ashley Chin. Effectiveness of Implanted Cardiac Rhythm Recorders With Electrocardiographic Monitoring for Detecting Arrhythmias in Pregnant Women With Symptomatic Arrhythmia and/or Structural Heart Disease: A Randomized Clinical Trial. JAMA Cardiol. 2020 Feb 19. doi: 10.1001/jamacardio.2019.5963

2020, Peer Reviewed Articles

Cardiac arrhythmia services in Africa from 2011 to 2018: the second report from the Pan African Society of Cardiology working group on cardiac arrhythmias and pacing.

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Bonny A, Ngantcha M, Yuyun M, Karaye KM, Scholtz W, Suliman A, Nel G, Aoudia Y, Kane A, Moustaghfi A, Okello E, Houenassi M, Sonou A, Niakara A, Lubenga YR, Adoubi A, Russel J, Damasceno A, Touré AI, Kane A, Tabane A, Jeilan M, Mbaye A, Tibazarwa K, Ben Ameur Y, Diakité M, Subahi S, Kaviraj B, Sani MU, Ajijola OA, Chin A, Sliwa K.  Cardiac arrhythmia services in Africa from 2011 to 2018: the second report from the Pan African Society of Cardiology working group on cardiac arrhythmias and pacing.  Europace. 2020 Jan 28. pii: euz354. doi: 10.1093/europace/euz354

2020,Peer Reviewed Articles

 

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