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Publications

2011

A not-so-rare form of heart failure in urban black Africans: pathways to right heart failure in the Heart of Soweto Study cohort
(July 1, 2011)

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Summary: Stewart S, Mocumbi AO, Carrington MJ, Pretorius S, Burton R, Sliwa K. A not-so-rare form of heart failure in urban black Africans: pathways to right heart failure in the Heart of Soweto Study cohort. Eur...
Keywords: Africa, Pulmonary arterial hypertension, Right heart failure
2011, Peer Reviewed Articles

Lessons from the Heart of Soweto Study and future directions
(March 1, 2011)
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Summary: Pretorius S, Stewart S, Sliwa K. Lessons from the Heart of Soweto Study and future directions. S Afr Heart J 2011; 8(2): 104-113.
Keywords: Africa, Heart of Soweto, Lessons, Methodology, tertiary care
2011, Peer Reviewed Articles

Natural polyphenols and cardioprotection
(February 28, 2011)

Summary: Lecour S, Lamont KT. Natural polyphenols and cardioprotection. Mini Reviews in Medicinal Chemistry, 2011,11(4):1191-1199 (December issue)
2011, Peer Reviewed Articles

Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning
(February 28, 2011)
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Summary: Somers S, Lacerda L, Opie L, Lecour S. Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning. Physiological Research, 2011, 60: 971-4
2011, Peer Reviewed Articles

Vagal Stimulation, Through its Nicotinic Action, Limits Infarct Size and the Inflammatory Response to Myocardial Ischemia and Reperfusion
(February 28, 2011)
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Summary: Calvillo L, Vanoli E, Andreoli E, Besana A, Modeo E, Gnecchi M, Zerbi P, Vago G, Busca G, Schwartz PJ. Vagal Stimulation, Through its Nicotinic Action, Limits Infarct Size and the Inflammatory Response to Myocardial...
2011, Peer Reviewed Articles

QTc Behavior During Exercise and Genetic Testing for the Long-QT Syndrome
(February 28, 2011)
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Summary: Schwartz P, Crotti L. QTc Behavior During Exercise and Genetic Testing for the Long-QT Syndrome. 2011;15;124(20):2181-4. (November)
2011, Peer Reviewed Articles

Antiphospholipid antibodies in black South Africans with HIV and acute coronary syndromes
(February 28, 2011)
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Summary: Becker AC, Libhaber E, Sliwa K, Singh S, Stewart S, Tikly M, Essop MR. Antiphospholipid antibodies in black South Africans with HIV and acute coronary syndromes: prevalence and clinical correlates. BMC Res Notes. 2011 Oct...
2011, Peer Reviewed Articles

Wine and heart: learning from the French paradox
(February 28, 2011)
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Summary: Opie LH, Lamont KT, Lecour S. Wine and heart: learning from the French paradox. SA Heart Journal, 2011,8(3):172-177 (October)
2011, Peer Reviewed Articles

The five-point heart healthy lifestyle
(February 28, 2011)
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Summary: Opie LH. The five-point heart healthy lifestyle. SA Heart Journal, 2011,8(3):154-163 (October)
2011, Peer Reviewed Articles

Delayed postconditioning: cardioprotection at the limit
(February 28, 2011)
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Summary: Opie LH, Lecour S. Delayed postconditioning: cardioprotection at the limit? Circulation 2011;124(12):1315-8 (September)
2011, Peer Reviewed Articles

A low-cost solar-powered blood-pressure device
Sliwa K, Stewart S
(February 28, 2011)
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Summary: Sliwa K, Stewart S. A low-cost solar-powered blood-pressure device. Lancet. 2011; 20;378(9792):647-8 (August)
2011, Peer Reviewed Articles

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome
Ackerman MJ, Albertson RM, Antzelevitch C, Crotti L, Giudicessi JR, Mugione A, Nesterenko VV, Schwartz PJ, Tester DJ, Ye D
(February 28, 2011)
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Summary: Giudicessi JR, Ye D, Tester DJ, Crotti L, Mugione A, Nesterenko VV, Albertson RM, Antzelevitch C, Schwartz PJ, Ackerman MJ.Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome. Heart...
2011, Peer Reviewed Articles

Dilated cardiomyopathy and potentially deadly digoxin
(February 28, 2011)
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Summary: Opie LH. Dilated cardiomyopathy and potentially deadly digoxin. S Afr Med J. 2011;May 25;101(6):388-390 (May)
2011, Peer Reviewed Articles

Working abroad: Professor Karen Sliwa discusses living and working in different environments
Sliwa K, Tofield A
(February 28, 2011)
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Summary: Sliwa K, Tofield A. Working abroad: Professor Karen Sliwa discusses living and working in different environments. Eur Heart J. 2011;May;32(9):1047-8. (May)
2011, Peer Reviewed Articles

Aspirin in the prevention of cancer
(February 27, 2011)
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Summary: Opie LH. Aspirin in the prevention of cancer. Lancet. 2011; 4;377(9778):1651 (May)
Keywords: Opie LH 2011,
Peer Reviewed Articles

Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure
Borggrefe M, Crijns HJ, De Ferrari GM, Dennert R, Gavazzi A, Klein H, Kuschyk J, Milasinovic G, Raspopovic S, Sanzo A, Schwartz PJ, Smid J, Swedberg K, Zabel M
(February 27, 2011)
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Summary: De Ferrari GM, Crijns HJ, Borggrefe M, Milasinovic G, Smid J, Zabel M, Gavazzi A, Sanzo A, Dennert R, Kuschyk J, Raspopovic S, Klein H, Swedberg K, Schwartz PJ; CardioFit Multicenter Trial Investigators. Chronic vagus...
2011, Peer Reviewed Articles

Effects of Sphingosine-1-Phosphate on Acute Contractile Heart Failure
Deshpande G, Lecour S and Opie LH, Mardikar H, McCarthy J
(February 27, 2011)
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Summary: Deshpande G, McCarthy J, Mardikar H, Lecour S and Opie LH. Effects of Sphingosine-1-Phosphate on Acute Contractile Heart Failure (ACHF). Cardiovasc Drugs Ther, 2010, 24:459–460. (December)
2011, Peer Reviewed Articles

Perspectives and perceptions on the consumption of a healthy diet in Soweto, an urban African community in South Africa
Pretorius S, Sliwa K
(February 27, 2011)
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Summary: Pretorius S, Sliwa K. Perspectives and perceptions on the consumption of a healthy diet in Soweto, an urban African community in South Africa. S Afr Heart J 2011; 8: 178-183.
2011, Peer Reviewed Articles

Trimetazidine reduces endogenous free fatty acid oxidation and improvs myocardial efficiency in obese humans.
Borra R, Bucci M, Cabiati M, Del Ry S, Iozzo P, Knuuti J, Maggio R, Nagren K, Nuutila P, Opie LH, Pagotto U, Parkka JP, Parkkola R, Rigazio S, Taittonen M, Tuunanen H, Viljanen T
(February 27, 2011)
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Summary: Bucci M, Borra R, Nagren K, Parkka JP, Del Ry S, Maggio R, Tuunanen H, Viljanen T, Cabiati M, Rigazio S, Taittonen M, Pagotto U, Parkkola R, Opie LH, Nuutila P, Knuuti J, Iozzo P....
2011, Peer Reviewed Articles

Pharmacological and non-pharmacological management of the congenital long QT syndrome: the rationale
Schwartz PJ(February 27, 2011)
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Summary: Schwartz PJ. Pharmacological and non-pharmacological management of the congenital long QT syndrome: the rationale. Pharmacol Ther 2011; 131(1): 171-177.
2011, Peer Reviewed Articles

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome
Ackerman MJ, Barsheshet A, Benhorin J, Buber J, Goldenberg I, Kaufman ES, McNitt S, Moss AJ, Peterson DR, Polonsky S, Robinson JL, Schwartz PJ, Towbin JA, Vincent GM, Zareba W, Zhang L

(February 27, 2011)
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Summary: Barsheshet A, Peterson DR, Moss AJ, Schwartz PJ, Kaufman ES, McNitt S, Polonsky S, Buber J, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Towbin JA, Vincent GM, Zhang L, Goldenberg I. Genotype-specific QT correction...
2011, Peer Reviewed Articles

Real-life observations of clinical outcomes with rhythm- and rate-control therapies for atrial fibrillation RECORDAF
Breithardt G, Camm AJ, Crijns H, Dorian P, Kowey P, Le Heuzey JY, Merioua I, Pedrazzini L, Prystowsky EN, Schwartz PJ, Torp-Pedersen C, Weintraub W
(February 27, 2011)
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Summary: Camm AJ, Breithardt G, Crijns H, Dorian P, Kowey P, Le Heuzey JY, Merioua I, Pedrazzini L, Prystowsky EN, Schwartz PJ, Torp-Pedersen C, Weintraub W. Real-life observations of clinical outcomes with rhythm- and rate-control therapies...
2011, Peer Reviewed Articles

Inhibition of the cerbral renin-angiotensin system to limit cognitive decline in elderly hypertensive persons
(February 27, 2011)
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Summary: Opie LH. Inhibition of the cerbral renin-angiotensin system to limit cognitive decline in elderly hypertensive persons. Cardiovasc Drugs Ther 2011; 25(4): 277-279.
2011, Peer Reviewed Articles

Feeding the emergence of advanced heart disease in Soweto: a nutritional survey of black African patients with heart failure
Pretorius S, Ruf V, Sliwa K, Stewart S, Walker K
(February 27, 2011)
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Summary: Pretorius S, Sliwa K, Ruf V, Walker K, Stewart S. Feeding the emergence of advanced heart disease in Soweto: a nutritional survey of black African patients with heart failure. Cardiovasc J Afr 2011; 21: 1-7.
2011, Peer Reviewed Articles

Elevated risk factors but low burden of heart disease in urban African primary care patients
Antras-Ferry J, Blauwet L, Carrington MJ, Ogah OS, Pretorius S, Sliwa K, Stewart S
(February 27, 2011)
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Summary: Stewart S, Carrington MJ, Pretorius S, Ogah OS, Blauwet L, Antras-Ferry J, Sliwa K. Elevated risk factors but low burden of heart disease in urban African primary care patients: A fundamental role for primary prevention....
2011, Peer Reviewed Articles

Controversies in the cardiovascular management of type 2 diabetes
Gersh BJ, Opie LH, Yellon DM
(February 27, 2011)
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Summary: Opie LH, Yellon DM, Gersh BJ. Controversies in the cardiovascular management of type 2 diabetes. Heart 2011; 97(1): 6-14.
2011, Peer Reviewed Articles

Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signalling pathways in ischemic postconditioning
Hausenloy DJ, Lecour S, Yellon DM
(February 27, 2011)
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Summary: Hausenloy DJ, Lecour S, Yellon DM. Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signalling pathways in ischemic postconditioning: two sides of the same coin. Antioxid Redox Signal 2011; 14(5): 893-907.
2011, Peer Reviewed Articles

The clinical consequences and challenges of hypertension in urban-dwelling black Africans
Abbasi H, Carrington M, Damasceno A, Hansen C, Libhaber E, Sliwa K, Stewart S, Wilkinson D
(February 27, 2011)
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Summary: Stewart S, Libhaber E, Carrington M, Damasceno A, Abbasi H, Hansen C, Wilkinson D, Sliwa K. The clinical consequences and challenges of hypertension in urban-dwelling black Africans: insights from the Heart of Soweto Study. Int...
2011, Peer Reviewed Articles

Long-term outcome of peripartum cardiomyopathy in a population with high seropositivity for human immunodeficiency virus
Becker A, Forster O, Hilfiker-Kleiner D, Libhaber E, Sliwa K, Tibazarwa K, Yip A
(February 27, 2011)
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Summary: Sliwa K, Forster O, Tibazarwa K, Libhaber E, Becker A, Yip A, Hilfiker-Kleiner D. Long-term outcome of peripartum cardiomyopathy in a population with high seropositivity for human immunodeficiency virus. Int J Cardiol 2011; 147(2): 202-208.
2011, Peer Reviewed Articles

The Thrombotic profile of treatment-naive HIV-positive black South Africans with acute coronary syndromes
Becker AC, Essop MR, Jacobson B, Libhaber E, Singh S, Sliwa K, Stewart S
(February 27, 2011)
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Summary: Becker AC, Jacobson B, Singh S, Sliwa K, Stewart S, Libhaber E, Essop MR. The Thrombotic profile of treatment-naive HIV-positive black South Africans with acute coronary syndromes. Clin Appl Thromb Hemost 2011; 17(3): 264-272.
2011, Peer Reviewed Articles

Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection
Lacerda L, Lamont KT, Lecour S, Opie LH, Somers S
(February 27, 2011)
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Summary: Lamont KT, Somers S, Lacerda L, Opie LH, Lecour S. Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection. J Pineal Res 2011; 50(4): 374-380
2011, Peer Reviewed Articles

Standing at the crossroads between new and historically prevalent heart disease: effects of migration and socio-economic factors in the Heart of Soweto cohort study
(February 27, 2011)
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Summary: Stewart S, Carrington M, Pretorius S, Methusi P, Sliwa K. Standing at the crossroads between new and historically prevalent heart disease: effects of migration and socio-economic factors in the Heart of Soweto cohort study. Eur...
2011, Peer Reviewed Articles

Vagal stimulation for heart diseases: from animals to men
Schwartz PJ
(February 27, 2011)
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Summary: Schwartz PJ. Vagal stimulation for heart diseases: from animals to men. An example of translational cardiology. Circulation 2011; 75: 20-27. 2011, Peer Reviewed Articles

The myth of QT shortening by weight loss and physical training in obese subjects with coronary heart disease
Caetani G, Gondoni LA, Montano M, Schwartz PJ, Titon AM
(February 27, 2011)
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Summary: Gondoni LA, Titon AM, Montano M, Caetani G, Schwartz PJ. The myth of QT shortening by weight loss and physical training in obese subjects with coronary heart disease. Obesity 2011; 19: 200-203. 2011, Peer Reviewed Articles

Vagal stimulation for heart failure
Schwartz PJ
(February 27, 2011)

Summary: Schwartz PJ. Vagal stimulation for heart failure. Curr Opin Cardiol 2011; 26: 51-54.
2011, Peer Reviewed Articles

PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3Β inhibition.
Essop MF, Lochner A, McCarthy J, Opie LH, Sack MN
(February 27, 2011)
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Summary: McCarthy J, Lochner A, Opie LH, Sack MN, Essop MF. PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3Β inhibition. J Cell Physiol 2011; 226(9): 2457-2468.
2011, Peer Reviewed Articles

Glycaemia and heart failure in diabetes types 1 and 2
(February 27, 2011)
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Summary: Opie LH. Glycaemia and heart failure in diabetes types 1 and 2. Lancet 2011; 378(9786): 103-104.
2011, Peer Reviewed Articles

Hypertension-Global Perspective
Gersh B, Sliwa K, Stewart S
(February 27, 2011)
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Summary: Sliwa K, Stewart S, Gersh B. Hypertension-Global Perspective. Circulation 2011; 123: 2892-2896.
2011, Peer Reviewed Articles

When are pro-inflammatory cytokines SAFE in heart failure?
James RW, Lecour S
(February 27, 2011)
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Summary: Lecour S, James RW. When are pro-inflammatory cytokines SAFE in heart failure? Eur Heart J 2011; 32(6): 680-685.
2011, Peer Reviewed Articles

Erythropoietin as a cardioprotective agent: down but not out
(February 27, 2011)
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Summary: Opie LH. Erythropoietin as a cardioprotective agent: down but not out. Heart 2011; 97(19): 1537-1539.
2011, Peer Reviewed Articles

Long-term outcome of peripartum cardiomyopathy in a population with high seropositivity for human immunodeficiency virus
Becker A, Forster O, Hilfiker-Kleiner D, Libhaber E, Sliwa K, Tibazarwa K, Yip A
(February 27, 2011)

Summary: Sliwa K, Forster O, Tibazarwa K, Libhaber E, Becker A, Yip A, Hilfiker-Kleiner D. Long-term outcome of peripartum cardiomyopathy in a population with high seropositivity for human immunodeficiency virus. Int J Cardiol 2011; 147(2): 202-208.
2011, Peer Reviewed Articles

Living longer, living better
(February 27, 2011)

Summary: Opie LH. Living longer, living better. Oxford University Press, February 2011, pp 1-198.
2011, Books

Peripartum Cardiomyopathy
(February 26, 2011)

Summary: Blauwet L, Sliwa K. Peripartum Cardiomyopathy. Obstetric Medicine 2011; OM-10-0054.R1.
2011, Peer Reviewed Articles

Barriers and challenges for primary and secondary prevention of heart disease in sub-Saharan Africa
Carrington MJ, Sliwa K, Stewart S
(February 24, 2011)
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Summary: Stewart S, Carrington MJ, Sliwa K. Barriers and challenges for primary and secondary prevention of heart disease in sub-Saharan Africa. S Afr Heart J 2011; 8(2): 96-102.
2011, Peer Reviewed Articles