Home > Research > The IMHOTEP-Study


The African Cardiomyopathy and Myocarditis Registry Programme (the IMOTEP Study) is a pan-African multi-centre prospective cohort study with four objectives: (1) to phenotype and classify patients with cardiomyopathy into familial and non-familial disease according to the European Society of Cardiology (ESC) criteria7; (2) to conduct genetic studies of causal genes in familial disease, and genetic association studies for susceptibility genes in cases of non-familial disease, (3) to establish the prevalence of myocarditis using CMR and histology at two centres where this capacity exists (Cape Town and Johannesburg), and (4) determine the outcome of cardiomyopathy in Africans.

This study is likely to yield novel insights into the molecular genetics of cardiomyopathy, the role of myocarditis in the pathogenesis of the disease, the outcome and determinants of morbidity and mortality.

UCT in collaboration with the Hatter Institute forCardiovascular Research in Africa and Groote Schuur Hospital will be hosting the first investigators meeting forThe African Cardiomyopathy and Myocarditis Registry Program.

We would like to extend the invitation to those interested in attending the

Expert Review Session on Friday 7th October 2016 from 8h15 – 18h00 at Wolfson Pavillion Lecture Theatre in IDM.

International (UK and USA) and African experts will be speaking on the genetics of cardiomyopathy, myocarditis, the role of Cardiovascular Magnetic Resonance Imaging and histopathology in cardiomyopathy and myocarditis.


All investigators, their institutions and their e-mail addresses:

South Africa - University of Cape Town: BM Mayosi, bongani.mayosi@uct.ac.za; K Sliwa, karen.sliwa@uct.ac.za; N Ntusi, n.ntusi@uct.ac.za; S Kraus, s.kraus@uct.ac.za; A Wonkam, ambroise.wonkam@uct.ac.za; N Laing, n.verkijk@uct.ac.za; G Shaboodien, gasnat.shaboodien@uct.ac.za; H Wainwright, helen.wainwright@uct.ac.za; M Badri, motasimb@hotmail.com. Walter Sisulu University: B Longo-Mbenza, longombenza@gmail.com; L Pepeta, dr.l.pepeta@gamil.com. Stellenbosch University: P Brink, pab@sun.ac.za; J Lawrenson, john.lawrenson@uct.ac.za. WITS: R Nethononda, thloni@worldonline.co.za; F Peters, ferande.peters@gmail.com; A Cilliers, amcilliers@icon.co.za; H Ntsinjana, hopewell.ntsinjana@wits.ac.za. Mozambique - Instituto Nacional de Saúde de Moçambique: A Mocumbi, amocumbi@yahoo.com. Kenya – Moi University: A Barasa, barasaceo12@gmail.com; G Bloomfield, Gerald.bloomfield@duke.edu. Nigeria – University of Abuja: D Ojji, dikeojji@yahoo.co.uk. Senegal – University of Dakar: S Ba, serigneabdou2@gmail.com. United Kingdom – University of Oxford: H Watkins, hugh.watkins@rdm.ox.ac.uk; S Neubauer, stefan.neubauer@cardiov.ox.ac.uk; V Ferreira, vanessa.ferreira@cardiov.ox.ac.uk; Masliza Mahmod, masliza.mahmod@cardiov.ox.ac.uk.  University of Manchester: B Keavney, bernard.keavney@manchester.ac.uk. University of Newcastle-upon-Tyne: H Cordell, heather.cordell@newcastle.ac.uk